Vitiligo Patients Can Undergo Novel Treatment With Shorter Disease Stability


A novel technique appears to be an effective treatment option for patients with vitiligo and shorter durations of disease stability, according to the findings of a recent study. This technique combines noncultured epidermal cell suspense (NCES) with noncultured dermal cell suspension (NDCS) transplantation to treat vitiligo.

The randomized clinical trial included 40 participants with focal, segmental, or generalized vitiligo with clinical stability for 3 to 6 months or for more than 12 months. Participants were divided into 2 groups based on clinical stability: 1) those with stability for 6 months or less; 2) those with stability for more than 12 months. Each group was divided into subgroups A and B. Participants in subgroups 1A and 2A underwent NCES alone and subgroups 1B and 2B underwent NCES and NDCS. The extent of repigmentation, pattern of repigmentation, and color match were assessed 24 weeks posttreatment.
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Among participants with clinical disease stability for 3 to 6 months, 10 participants who underwent NCES and NDCS experienced greater than 75% repigmentation after 24 weeks compared with 3 participants who underwent NCES alone (100% vs 30%, respectively). The researchers observed similar results among 6 participants in group 2 who underwent NCES alone and 7 participants who underwent NCES and NCDS (60% vs 70%). They did not find any significant differences in pattern of repigmentation and color matching between both groups and subgroups.

“Combination of NCES and NDCS resulted in excellent response in participants with vitiligo with shorter duration of clinical stability compared with NCES alone,” the researchers concluded. “This combination may be used early in the course of stable vitiligo without waiting for a period of 12 months or more since last clinical activity.”


Thakur V, Kumar S, Kumaran MS, Kaushik H, Srivastava N, Parsad D. Efficacy of transplantation of combination of noncultured dermal and epidermal cell suspension vs epidermal cell suspension alone in vitiligo: A randomized clinical trial [Published online January 02, 2019]. JAMA Dermatol. doi:10.1001/jamadermatol.2018.4919