“Given the widespread use of systemic antibiotics for treatment of moderate to severe acne, it is important to understand the associations of such antibiotic use with changes not only in Cutibacterium acnes (formerly Propionibacterium acnes),” the researchers wrote, “but also in the complete bacterial community of the skin.”
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After 4 weeks of treatment, researchers identified a 1.4-fold reduction in the level of Cutibacterium acnes across all 4 participants, with recovery after minocycline was discontinued. They also reported a transient 5.6-fold increase in the relative abundance of Pseudomonas species immediately following antibiotic treatment.
Eight weeks after antibiotic cessation, researchers found a persistent 1.7-fold increase in the relative abundance of Streptococcus species as well as a 4.7-fold decrease in the relative abundance of Lactobacillus species.
“Understanding the association between systemic antibiotic use and skin microbiota,” the researchers wrote, “may help clinicians decrease the likelihood of skin comorbidities related to microbial dysbiosis.”
Chien AL, Tsai J, Leung S, et al. Association of systemic antibiotic treatment of acne with skin microbiota characteristics [published online February 13, 2019]. JAMA Dermatology. doi:10.1001/jamadermatol.2018.5221