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Topical Fusidic Acid Improves PIH Following CO2 Lasers for Acne Scars

A recent study found less inflammation and great improvement in postinflammatory hyperpigmentation (PIH) among patients with acne scars treated with fusidic acid cream following ablative fractional (Fr) CO2 laser therapy.

The researchers compared the efficacy of fusidic acid cream with erythromycin ointment (control) as a postoperative treatment following ablative Fr CO2 laser treatment. A total of 60 Chinese participants with atrophic acne scars applied either fusidic acid or erythromycin ointment for 7 days. Follow up visits were conducted at weeks 8 and 12. The researchers assessed baseline and postoperative inflammation and PIH by facial examination, photographs, and questionnaires, and PIH was also assessed using the Hyperpigmentation Activity and Severity Index (HASI) and a 5-point grading system.

Both groups had moderate to severe PIH, the researchers said. At weeks 8 and 12, they found the mean HASI score and severity of PIH in the experimental group were lower compared with the control group.

One patient developed postoperative abscesses and one patient developed papules in the control group, while no inflammation was observed among participants in the experimental group, the researchers said.

“Fusidic acid cream shows promise as a common treatment after ablative Fr CO2 therapy to reduce postoperative inflammation and PIH,” they concluded.


Wei M, Li L, Zhang XF, Li M, Wang B, Yan Y. Fusidic acid cream comparatively minimizes signs of inflammation and postinflammatory hyperpigmentation after ablative fractional CO2 laser resurfacing in Chinese patients: a randomized controlled trial. J Cosmet Dermatol. Published online September 26, 2020. doi:10.1111/jocd.13735

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