Patients with psoriasis did not have an elevated risk for suicide, however psoriasis was associated with a higher prevalence of mental health comorbidities, according to the findings of a recent study.
The researchers identified 56,961 individuals with psoriasis enrolled in the Clinical Practice Research Datalink and linked the data to the Hospital Episode and Statistics and Office for National Statistics Mortality records. They matched individuals with psoriasis to 876,919 people without psoriasis based on age, gender, and general practice. Hazard ratios (HR) were calculated to determine the risk of suicide and fatal self-harm, which were adjusted for socioeconomic status.
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At baseline, individuals with psoriasis had a higher prevalence for histories of alcohol misuse, bipolar disorder, depression, anxiety, self-harm, and psychotropic drug prescription. While individuals with psoriasis had a lower risk for suicide (HR 0.59, 95% CI 0.41‐0.85), the risk varied according to age. Those aged 40 years and older at diagnosis had a lower suicide risk (HR 0.38, 0.21‐0.66), while there was no difference in suicide risk among individuals diagnosed before age 40 (HR 0.92, 0.58‐1.46). However, there was a small increase in the risk of self-harm among those with psoriasis (HR 1.15, 1.04‐1.27).
“Healthcare professionals caring for patients with psoriasis should continue to monitor and tackle effectively the psychological needs of these individuals,” the researchers concluded.
Parisi R, Webb RT, Kleyn CE, et al. Psychiatric morbidity and suicidal behaviour in psoriasis: a primary care cohort study [published online July 14, 2018]. Br J Dermatol. doi:10.1111/bjd.17004