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Study Suggests Adjuvant Vitamin D Supplementation May Improve Clinical AD Outcomes

Adding vitamin D supplementation to topical steroid treatment may help improve clinical outcomes for patients with severe atopic dermatitis (AD), according to the findings of a recent study.

“Vitamin D supplementation with standard treatment yielded positive clinical outcomes in mild and moderate AD; however, the potential benefit of vitamin D in severe cases remains unclear,” the researchers said. They investigated the impact of vitamin D supplementation on response to standard treatment among 86 pediatric patients with severe AD. In addition to baseline topical 1% hydrocortisone cream, patients were randomized to either vitamin D3 1600 IU per day or placebo for 12 weeks. 

Change in mean Eczema Area and Severity Index (EASI) score and the mean percent change in EASI score from baseline to week 12 were assessed as the primary endpoints.

After 12 weeks, the researchers found patients who received vitamin D supplementation achieved significantly higher levels of 25 hydroxy vitamin D compared with those who did not receive supplementation.

Compared with the placebo group, the vitamin D treatment group had significantly lower mean EASI scores, the researchers said. In addition, the percent change in EASI score from baseline to week 12 differed significantly between the supplement and placebo groups, they added.

“Vitamin D supplementation could be an effective adjuvant treatment that improves the clinical outcomes in severe AD,” the researchers concluded.


Mansour NO, Mohamed AA, Hussein M, et al. The impact of vitamin D supplementation as an adjuvant therapy on clinical outcomes in patients with severe atopic dermatitis: a randomized controlled trial. Pharmacol Res Perspect. Published online November 3, 2020. doi:10.1002/prp2.679

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