SCC Risk Higher For Patients With AD


Patients with atopic dermatitis (AD) have an increased risk for developing squamous cell carcinoma (SCC), according to the findings of a recent study.

The retrospective study included 399 patients with a history of SCC and 780 age- and sex-matched controls who were seen at the Mayo Clinic between January 1, 1996 through December 23, 2010.
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After adjusting for smoking history, ionizing radiation exposure, corticosteroid and cyclosporine use, race, and non-SCC skin cancers, the researchers found that patients with AD had a 1.75 higher risk of developing SCC compared with those without a history of AD (95% CI, 1.05-2.93).

“Our findings support an increased risk of SCC development in the setting of AD,” the researchers concluded.

—Melissa Weiss


Cho JM, Davis DMR, Wetter DA, Bartley AC, Brewer JD. Association between atopic dermatitis and squamous cell carcinoma: a case–control study [published online December 15, 2017]. Int J Dermatol. doi:10.1111/ijd.13857