Psoriasis Patients Underdiagnosed For CV Risk Factors
Many patients with psoriasis and psoriatic arthritis (PsA) are often underdiagnosed and undertreated for cardiovascular (CV) risk factors including hypertension and dyslipidemia, a recent study found.
For their study, the researchers assessed 2554 patients with psoriatic disease (41.1% with psoriasis, 58.9% with PsA) enrolled in the Psoriasis and Arthritis Research Team cohort. Mean patient age was 52 years.
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The researchers evaluated each patient for the presence of modifiable CV risk factors such as diabetes, hypertension and dyslipidemia, as well as the use of appropriate therapies. The Framingham risk score was used to determine patients’ 10-year CV risk, and regression analysis was performed to identify predictors of undertreatment. Physician adherence to treatment guidelines was also assessed.
Results showed that 87.6% of patients had at least 1 modifiable CV risk factor. Of these patients, 45.1% had hypertension, 49.4% had dyslipidemia, 13.3% had diabetes, 75.3% had overweight or obesity, 54.3% had central obesity, and 17.3% were current smokers.
Ultimately, 59.2% of patients with hypertension and 65.6% of patients with dyslipidemia were found to be undertreated. In this cohort, younger age, the presence of psoriasis, and male sex predicted undertreatment.
“In real-world settings, a large proportion of patients with psoriasis and PsA were underdiagnosed and undertreated for [hypertension] and dyslipidemia,” the researchers concluded. “Strategies to improve the management of [CV risk factors] in psoriatic patients are warranted.”
Eder L, Harvey P, Chandran V, et al. Gaps in diagnosis and treatment of cardiovascular risk factors in patients with psoriatic disease: an international multicenter study [Published online February 1, 2018]. J Rheumatol.https://doi.org/10.3899/jrheum.170379.