The use of pneumatic-assisted high velocity jet injections as an alternative method for intradermal delivery of hyaluronic acid (HA) may be effective in improving various aesthetic skin concerns, according to a study published in Journal of Cosmetic Dermatology.
The researchers retrospectively compared the clinical efficacy of the delivery method using either noncrosslinked HA (NCL-HA) or crosslinked HA (CL-HA). In total, the charts of 115 patients treated with jet injected NCL-HA or CL-HA for skin rejuvenation, age-related laxity and rhytidosis, hypertrophic and acne scars, and striae were analyzed. At the 3-month follow-up, Global Aesthetic Improvement Scale (GAIS) and the 5-grade patient satisfaction scale were used to assess treatment efficacy, which was separately analyzed between patients receiving NCL-HA vs CL-HA. Additionally, longevity of treatment effect was measured by the time to voluntary return for repeat treatment.
The results found that each patient averaged 2.8 treatments with a low incidence of side effects including bruises (7%) and temporary local edema (1%). In addition, patient’s average satisfaction scores of 3.68 (NCL-HA) and 3.76 (CL-HA) revealed high satisfaction with treatment results in all categories. The average GAIS scores were 1.7 ("much improved") for neck, décolleté and perioral areas while 1.78 (NCL-HA) and 1.6 (CL-HA) were calculated overall. Finally, longevity of the effect averaged 13.1 months for NCL-HA and 13.2 months for CL-HA groups.
The authors concluded that their “retrospective data showed similar significant improvement of all aesthetic skin concerns in 115 [patients] treated with either NCL-HA or CL-HA delivered intradermally by a high velocity jet-injector device with minimal downtime, pain, or side-effects.” —Jessica Garlewicz
MacGillis D, Vinshtok Y. High-velocity pneumatic injection of non-crosslinked hyaluronic acid for skin regeneration and scar remodeling: a retrospective analysis of 115 patients. J Cosmet Dermatol. Published online February 12, 2021. doi:10.1111/jocd.14002