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Ocular Symptoms Are Common Among Patients With AD

A recent study found a high burden of ocular surface disorders and related symptoms in patients with moderate to severe atopic dermatitis (AD).

“Patients with AD have a greater risk of conjunctivitis and other ocular surface disorders than the general population,” the researchers wrote. In a randomized, placebo-controlled, phase 3 trial, they evaluated the burden of ocular surface disorders and related symptoms among patients with moderate to severe AD prior to starting treatment.

A total of 740 patients were enrolled in the trial and were screened for a 12-month history of ocular disorders. Of this, 712 patients completed a survey at baseline regarding the frequency and severity of ocular symptoms experienced in the past month.

At screening, 286 of 740 patients (38.6%) reported having at least one ocular disorder in the past year, the researchers said. In addition, 499 of 712 patients (70.1%) reported having at least one ocular symptom within the past month, with 4.4%, 6%, 5.5%, and 4.4% reported having discomfort, itching, redness, and tearing all of the time, respectively.

They also found 26.1%, 33.7%, 30.8%, and 31.6% of patients reported mild discomfort, itching, redness, and tearing, respectively, while 7.3%, 7.7%, 6.2%, and 4.2% of patients reported severe discomfort, itching, redness, and tearing, respectively.

“Dermatologists should be aware of increased incidence of these disorders in AD and query their patients for signs and symptoms of eye disease,” the researchers concluded.

Reference

Weyne J, Blauvelt A, de Bruin-Weller M, et al. Patient-reported ocular disorders and symptoms in adults with moderate-to-severe atopic dermatitis: screening and baseline survey data from a clinical trial. Dermatol Ther (Heidelb). Published online October 12, 2020. doi:10.1007/s13555-020-00456-x

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