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OCTA to Assess Vascular Status in of the Macula in Patients With Psoriasis

A prospective, cross-sectional, multicenter study investigated the vascular status of the macula in patients with psoriasis who showed no prior history of ocular inflammation using Optical Coherence Tomography Angiography (OCTA).

The study consisted of 55 patients with psoriasis and 55 healthy controls who underwent a complete eye examination and 6- × 6-mm OCTA imaging. The research group analyzed retinal vascular status as well as additional values collected included foveal thickness and avascular zone, clinical variables, including best corrected visual acuity (BCVA), intraocular pressure, and refractive condition were collected.

The results revealed that BCVA, intraocular pressure, and refractive condition were comparable between both the patients with psoriasis and the controls. OCTA imaging showed that superficial vascular plexus (wVD) and superficial parafoveal vascular density (pVD) were lower in the psoriasis group vs the controls (P=.009 and P=.01, respectively). Similarly, deep wVD and pVD were lower in the psoriasis group vs controls (P=.03 and P=.01, respectively). In a subanalysis of 47 patients with psoriasis but without psoriatic arthritis, lower values of wVD and pVD were registered in both the superficial and deep capillary plexuses.

It was determined that OCTA is a valuable tool that supplies data on vascular status of the retina in psoriasis without ocular involvement. Additionally, data on vascular density  may determine that vascular changes can occur earlier than clinical onset of posterior inflammation. —Jessica Garlewicz



Castellino N, Longo A, Fallico M, et al. Retinal vascular assessment in psoriasis: a multicenter study. Front Neurosci. Published online January 25, 2021. doi:10.3389/fnins.2021.629401

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