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Liver Disease Detectable With Elastography in Psoriasis

A recent study showed using ultrasound and elastography of the liver could help diagnosis steatosis and fibrosis in patients with psoriasis.

“Several studies have reported that non-alcoholic fatty liver disease is more frequent in patients with psoriasis, but few have reviewed the presence of liver fibrosis in those patients,” the researchers said.

In the cross-sectional cohort, single-center study, the researchers recruited 71 patients with moderate to severe psoriasis who visited a psoriasis unit at a tertiary hospital. Liver ultrasound was used to assess the grade of liver steatosis, and transitional vibration-controlled elastography was used to measure the quantity of liver fibrosis.
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The maximum historical Psoriasis Area and Severity Index (PASI) average was 14.4, while the baseline PASI average at the time of the study was 2, the researchers noted.

Overall, 36% of patients met the criteria for metabolic syndrome and 52% had steatosis. Steatosis was significantly related to male sex, metabolic syndrome comorbidities, elevated aspartate transaminase/alanine transaminase enzymes, dyslipidemia, and high initial PASI, the researchers said. Moderate liver fibrosis was found in 14% of patients, with 30% found to have liver steatosis observed on ultrasound, they added.

“Elastography may be a useful tool along with ultrasound to evaluate liver disease in patients with psoriasis,” the researchers concluded.


Magdaleno-Tapial J, Valenzuela-Oñate C, Ortiz-Salvador JM, et al. Prevalence of non-alcoholic fatty liver and liver fibrosis in patients with moderate-severe psoriasis: A cross-sectional cohort study [published November 15, 2019]. Australas J Dermatol. doi:10.1111/ajd.13175


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