According to the findings of a recent study, iron deficiency was identifiable in 75% of participants with hidradenitis suppurativa (HS).
“Iron deficiency is frequently present in inflammation-mediated chronic diseases, irrespective of anemia,” the researchers noted. They investigated iron status using serum concentrations of ferritin, transferrin saturation (Tsat), soluble transferrin receptor, and hepcidin among 74 participants with HS and 44 healthy controls. Iron deficiency was defined as ferritin levels below 100 µg/L or ferritin levels from 100 to 299 µg/L with Tsat below 20%.
Compared with controls, participants with HS were more likely to have a deranged iron status, the researchers said, with decreased levels of ferritin, Tsat, and hepcidin. “There was also a trend towards higher values of soluble transferrin receptor,” they added. Additionally, the researched observed that disease severity did not differentiate iron status biomarkers.
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Overall, 75% of participants with HS had iron deficiency. The prevalence of iron deficiency was not related to disease severity, and none of the iron status biomarkers correlated with levels of interleukin 6, the researchers added.
“The majority of patients with HS demonstrated derangements in iron status typical of iron deficiency,” which were not related to proinflammatory activation or associated with disease severity, the researchers concluded. “Whether it may have a therapeutic impact needs to be further studied,” they added.
Ponikowska M, Matusiak L, Kasztura M, Jankowska EA, Szepietowski JC. Deranged iron status evidenced by iron deficiency characterizes patients with hidradenitis suppurativa [published online January 10, 2020]. Dermatology. 2020;236(1):51-57. doi:10.1159/000505184