How Psoriasis Affects Type 1 Diabetes
Previous evidence has indicated an association between psoriasis and insulin resistance characteristic for type 2 diabetes. However, less is currently known about how this condition affects the clinical course of type 1 diabetes.
To explore this further, the researchers assessed 14 patients who received a type 1 diabetes diagnosis between 2002 and 2011 for the presence of psoriasis. These patients were propensity-score-matched with controls with type 1 diabetes only (n = 140) based on sex and duration of diabetes.
Type 1 diabetes-onset parameters and metabolic control surrogates were collected from 6 months following type 1 diabetes diagnosis.
A total of 129 of 140 controls were eligible for the present analysis. Results showed that, at onset, patients with type 1 diabetes and psoriasis had higher concentrations of C-peptide (median:0.38 ng/ml) vs controls (0.15 ng/ml). The researchers also found that, 6 months later, patients with type 1 diabetes and psoriasis had non-significantly lower hemoglobin A1c (HbA1c; 6.0% vs 6.6%), total cholesterol (143 mg/dl vs 159 mg/dl), and high-density lipoprotein (HDL) cholesterol (54.5 mg/dl vs 59 mg/dl) compared with controls.
“Patients with [type 1 diabetes] and psoriasis present higher endogenous insulin secretion at [type 1 diabetes] onset and a tendency for better glycemic control during the first 6 months,” the researchers concluded.
Michalak A, Koptas M, Świercz A, et al. Coexisting psoriasis affects the clinical course of type 1 diabetes in children. Pediatr Endocrinol Diabetes Metab. 2017;23(3):139-145. doi:10.18544/PEDM-23.03.0085.