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Is Down Syndrome Associated With HS?

Patients with Down syndrome are more likely to develop hidradenitis suppurativa (HS) and at a younger age compared with individuals without Down syndrome, according to the findings of a recent systematic review and meta-analysis.

While several follicular disorders have been associated with Down syndrome, including HS, studies on this topic are limited, the researchers wrote. To investigate this association and characterize HS in patients with Down syndrome, the researchers searched the literature using MEDLINE, Embase, Web of Science, and CENTRAL databases. They performed random-effects meta-analyses to assess the characteristics of patients with HS and Down syndrome compared with those with HS without Down syndrome and to determine the prevalence or association between HS and Down syndrome compared with individuals without Down syndrome.

A total of 12 studies, with 358 patients, were included.

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According to pooled analysis, the researchers found that individuals with Down syndrome presented with new onset HS at a significantly younger age compared with those without Down syndrome (mean difference -6.24; 95% CI, -10.01 to -2.24).

In addition, the researchers found a significantly increased odds of HS among patients with Down syndrome (odds ratio, 9.61; 95% CI, 5.70-16.20)

“Our findings suggest an association between HS and Down syndrome, with patients with Down syndrome suffering from an earlier onset of HS symptoms compared to patients without Down syndrome,” the researchers concluded.


Lam M, Lai C, Almuhanna N, Alhusayen R. Hidradenitis suppurativa and Down syndrome: a systematic review and meta‐analysis. Pediatr Dermatol. Published online September 6, 2020. doi:10.1111/pde.14326

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