Does Vitamin D Affect Eczema Risk?


atopic dermatitis

A recent study found an association between vitamin D levels and the risk for developing atopic dermatitis (AD)

While previous evidence has suggested low vitamin D levels were a potential risk factor for AD, the relationship was unclear. 
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Using data from the 2005 through 2006 US National Health and Nutrition Examination Survey, the researchers examined the association between AD and serum 25-hydroxyvitamin D (25[OH]D) levels among 3921 adults. Analyses adjusted for patient demographics, lifestyle variables, stress, medical comorbidities, and were stratified by race.

The researchers found that the prevalence of ever-reported AD was 7.94%. Individuals with higher socioeconomic status, depressive symptoms, history of asthma or hay fever, who were female, sampled in summer, and non-Hispanic white were more likely to report having AD.

Analyses showed individuals with vitamin D deficiency, defined as less than 50 nmol/L, had higher odds of AD compared with those with levels greater then 75 nmol/L (odds ratio 1.81; 95% CI, 1.09-3.01). In addition, the researchers found an inverted U-shaped association between AD and serum 25(OH)D levels. The highest risk for AD was at approximately 45 nmol/L, the researchers wrote, “with decreasing risk in both directions away from this value." 

However, the relationship between vitamin D levels and AD was not found among non-Hispanic black individuals.

 “Vitamin D is associated with reports of [AD] in non‐Hispanic white population, but not in the non‐Hispanic black population in the US,” the researchers concluded. 


Wei J, Jaleel T, MacLeod AS, Ji JS. Inverted U‐shaped relationship between vitamin D and ever‐reported eczema in US adults [published online December 27, 2018]. Allergy. doi:10.1111/all.13708