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Does Psoriasis Increase ESRD Risk?

Patients with psoriasis may have a higher risk for developing end-stage renal disease (ESRD), according to the findings of a recent study.

“Psoriatic patients may have a variety of comorbidities, but their risk of ESRD, particularly according to the subtype of psoriasis, is unclear,” the researchers said. They investigated the risk of ESRD among 530,307 individuals with psoriasis compared with 1,590,921 controls enrolled in a nationwide population-based cohort study, as well as the risk of ESRD based on subtype and use of systemic therapies.

A total of 1434 individuals with psoriasis developed ESRD during follow up.
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Psoriasis was associated with the risk of ESRD after adjusting for confounding factors, the researchers said, with a hazard ratio (HR) of 1.58 (95% CI, 1.47-1.68). Compared with the control group, individuals with psoriatic arthritis had a higher risk of ESRD (HR 7.60; 95% CI, 1.90-30.41).

“Interestingly, no such association was detected in the systemically treated group (HR 1.07; 95% CI, 0.80–1.41),” the researchers added. Compared with the non-systemically treated group, participants treated with acitretin had a lower risk of ESRD (HR 0.658; 95% CI, 0.494-0.875).

“In conclusion, the risk of developing ESRD in patients with psoriasis differed according to the type of treatment and the presence of arthritis,” the researchers concluded.


Lee E, Han JH, Bang CH, et al. Risk of end-stage renal disease in psoriatic patients: Real-world data from a nationwide population-based cohort study [published online November 12, 2019]. Sci Rep. doi:10.1038/s41598-019-53017-4

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