Do Vitamin D Levels Affect Psoriasis Severity?


Vitamin D levels could be associated with psoriasis severity, according to the findings of a recent study. However, vitamin D supplementation did not appear to benefit individuals with psoriasis.

The randomized, double-blind, placebo-controlled trial included 101 participants with psoriasis who were grouped by severity. For 12 months, 67 participants received 100,000 IU vitamin D3 after an initial 200,000 IU dose at baseline and 34 participants received placebo. Serum 25 (OH) concentrations and Psoriasis Area Severity Index (PASI) were measured every 3 months. The researchers assessed changes in PASI between groups over time, as well as the relationship between 25(OH)D levels and PASI.

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Although PASI did not differ between groups during the study, the researchers observed increases in 25(OH)D levels in both groups, rendering their findings inconclusive.

However, they found a significant inverse relationship between PASI and 25(OH)D, with an elevation of 25(OH)D by up to 125 nmol/L associated with mild decreases in PASI.

“A direct benefit of vitamin D3 supplementation for psoriasis could not be determined,” the researchers concluded. “However, these findings suggest a relationship between 25(OH)D and psoriasis severity, at least in some subgroups.”


Ingram MA, Jones MB, Stonehouse W, Jarrett P, Scragg R, Mugridge O. Oral vitamin D3supplementation for chronic plaque psoriasis: A randomized, double-blind, placebo-controlled trial [Published online February 26, 2018]. J Dermatol Treatment.