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Combination Regimen with Licochalcone A Improves Mild Acne

A recent multicenter, prospective study showed a daily regimen that consisted of licochalcone A combined with salicylic acid and hydroxy-complex 10% improved mild acne.

In the study, the researchers assessed the efficacy and tolerability of a new daily cosmetic regiment among 91 participants with mild acne. Participants applied licochalcone A combined with salicylic acid and L-carnitine in the morning and a cream with licochalcone A and hydroxy-complex 10% at night for 8 weeks. The Global Acne Grading System (GAGS) score, comedones and papules lesion counts, and imaging were used to assess the efficacy of this regimen at baseline and weeks 4 and 8.

The researchers observed a statistically significant reduction in GAGS after 4 weeks of treatment. In addition, they found that the mean total count of comedones had been significantly reduced by 41% and papules by 45% from baseline. A significant reduction in mean sebum (47%) was also observed.
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After 8 weeks of treatment, the researchers noted statistically significant reductions from baseline in GAGS, total count of comedones and papules (64% and 71%, respectively), and additional sebum reductions (52%).

“Our results suggest that the daily regimen based on Licochalcone A with salicylic acid and L-carnitine as fluid or with Hydroxy-Complex 10% as cream represent an interesting cosmetic approach for treating mild acne,” the researchers concluded.


Dall'Oglio F, Fabbrocini G, Tedeschi A, Donnarumma M, Chiodini P, Micali G. Licochalcone A in combination with salicylic acid as fluid based and hydroxy-complex 10% cream for the treatment of mild acne: A multicenter prospective trial. Clin Cosmet Investig Dermatol. 2019;12:961–967. doi:10.2147/CCID.S206935

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