AD Linked to Cardiovascular Outcomes

chest cavity

A recent systematic review found significant associations between cardiovascular outcomes and atopic dermatitis (AD) among cohort studies.

In the review, the researchers identified 19 studies using MEDLINE, Embase, and Global Health databases. They calculated pooled estimates and the effect of increasing AD severity on cardiovascular outcomes.
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“The effects of atopic eczema reported in cross-sectional studies were heterogeneous, with no evidence for pooled associations with angina, myocardial infarction, heart failure, or stroke,” the researchers wrote.

In analyses of cohort studies, the researchers found AD was associated with an increased risk of myocardial infarction, stroke, ischemic stroke, and heart failure, with wide prediction intervals for myocardial infarction and stroke.

Additionally, the risk for developing cardiovascular outcomes appeared to increase with increasing severity of AD. 

“Significant associations with cardiovascular outcomes were more common in cohort studies but with considerable between-study heterogeneity,” the researchers concluded. “Increasing atopic eczema severity was associated with increased risk of cardiovascular outcomes. Improved awareness amongst stakeholders regarding this small significant association is warranted.”


Ascott A, Mulick A, Yu A, et al. Atopic eczema and major cardiovascular outcomes: a systematic review and meta-analysis of population-based studies [published online December 18, 2018]. J Allergy Clin Immunol. doi:10.1016/j.jaci.2018.11.030