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Is AD Associated With Celiac Disease?

A recent study showed a significant association between atopic dermatitis (AD) and celiac disease.

The cross-sectional, observational study included 116,816 patients enrolled in a large health management organization who were diagnosed with AD from 2002 to 2017. Among these patients, 45,157 were adults and 1909 adult patients had moderate to severe AD. The presence of celiac disease and celiac disease-related morbidities were identified among all patients with AD, adults with AD, and adults with moderate to severe AD, and compared with controls without AD.
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The prevalence rate of celiac disease among all patients with AD was 0.6% vs 0.4% among controls; was 0.6% among adults with AD vs 0.3% among matched controls; and was 0.8% among adults with moderate to severe AD vs 0.3% among matched controls.

In multivariate analysis, researchers found AD was associated with significantly higher prevalence of celiac disease (odds ratio 1.609; 95% CI, 1.42-1.82) in the entire study population and each subgroup.

“This association emphasizes the need for timely screening of gastrointestinal morbidities in individuals with atopic dermatitis to prevent long-term complications,” the researchers concluded.


Shalom G, Kridin K, Raviv KO, et al. Atopic dermatitis and celiac disease: A cross-sectional study of 116,816 patients [published online November 2, 2019]. Am J Clin Dermatol. doi:10.1007/s40257-019-00474-2

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