Volume 12 - Issue 8 - August 2004

A common perception related to the use of topical retinoid therapy is that initial exacerbation of acne commonly precedes clinical improvement. Market research and informal surveys that I have completed suggest that many dermatologists limit the use of topical retinoids when initiating acne therapy due to concern regarding initial exacerbation. A second observation. likely related to previous availability and usage of formulations associated with a high incidence of irritation, is that clinical results are optimized only if irritation is induced by topical retinoid therapy. The availabili