Volume 12 - Issue 2 - February 2004

A ging is a complex process dictated by an inherent genetic program and accelerated by environmental damage to genes and their protein products. Aging reduces maximal capacity and functional reserve of all organs in the body, ultimately to a point incompatible with life. This article reviews the recognized age-associated changes in skin and their pathophysiology and mechanism of treatment responsiveness, when known. It also explores current thoughts regarding the molecular basis of aging and its evolutionary value. Clinical Impact of Skin Aging Human skin is the body’s dynamic inter