Do Psychological Factors Contribute to Psoriasis Non-Adherence?


Researchers conducted a systematic literature review of 73 published studies to identify factors associated with treatment non-adherence across diseases in rheumatology, gastroenterology and dermatology. The studies were listed in PubMed, Science Direct, PsychINFO and the Cochrane Library and published from January 1, 1980 to February 14, 2014.

Studies eligible for the review included patients with a diagnosis of rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, inflammatory bowel disease or psoriasis and included statistics to examine associations of factors with non-adherence, according to the researchers.

Using a standardized 23-item form they determined that demographic or clinical factors were not consistently associated with non-adherence. There was inadequate evidence suggesting an association between non-adherence and treatment factors, such as dosing frequency. 

“Consistent associations with adherence were found for psychosocial factors, with the strongest evidence for the impact of the healthcare professional–patient relationship, perceptions of treatment concerns and depression, lower treatment self-efficacy and necessity beliefs and practical barriers to treatment. Interventions designed to address these factors may be most effective in tackling treatment non-adherence,” the researchers concluded. 


Vangeli E, Bakshi S, Baker A, et al. A systematic review of factors associated with non-adherence to treatment for immune-mediated inflammatory diseases. Adv Ther. 2015;32(11):983-1028.