Psoriasis Patients May Be at Risk for Liver Disease

The prevalence of non-alcoholic fatty liver disease (NAFLD) in psoriasis patients was evaluated in a cross-sectional study, recently published in Journal of the European Academy of Dermatology and Venereology. For the study, researchers set out to determine the risk of liver fibrosis in these patients with psoriasis. 

The study included 124 patients with psoriasis and 79 healthy controls. After excluding other secondary causes of chronic liver disease, NAFLD was diagnosed in the presence of characteristic sonographic features of fatty liver. NAFLD fibrosis score (NAFLD-FS) were used to measure the risk of advanced liver fibrosis.

Patients with psoriasis had a greater prevalence of NAFLD than the healthy controls (44% vs 26%, respectively; P<.001). In addition, patients with psoriasis also scored higher in the NAFLD-FS, suggesting a higher risk of liver fibrosis, than the healthy controls (−1.57 ± 1.4 vs −3.10 ± 1.5, mean ± SD; P<.0001).

The researchers concluded that individuals with psoriasis should be screened for common causes of liver disease, such as NAFLD and liver fibrosis. “Psoriasis resulted in a significant predictor of advanced liver fibrosis independently of age, sex, BMI [body mass index], hypertension and diabetes in the multivariate analysis,” they said. 


Gisondi P, Barba E, Girolomoni G. Non-alcoholic fatty liver disease fibrosis score in patients with psoriasis. J Eur Acad Dermatol Venereol. Published online ahead of print November 4, 2015.