Oxidation Reduction Critical for the Resolution of Psoriatic Plaques
Narrowband UVB (NB-UVB) phototherapy is used for treatment of psoriasis, though the mechanisms underlying its efficacy are unclear. In a recent study, researchers used gene expression profiling to characterize gene expression in lesional epidermis from psoriasis patients in the middle and late stages of NB-UVB phototherapy. The earliest response to phototherapy was increased melanogenesis gene expression.
At the conclusion of treatment, genes responding to phototherapy and correlated to treatment outcome were involved in oxidation reduction, growth and mitochondria organization. They found that SPATA18, a key regulator of mitochondrial quality, was significantly down regulated in psoriasis (P <0.05). Poly(dA:dT) and poly(I:C) stimulation increased SPATA18 level in primary keratinocytes, indicating the importance of mitochondria quality control underinnate immune induced oxidative stress.