Oxidation Reduction Critical for the Resolution of Psoriatic Plaques

Narrowband UVB (NB-UVB) phototherapy is used for treatment of psoriasis, though the mechanisms underlying its efficacy are unclear. In a recent study, researchers used gene expression profiling to characterize gene expression in lesional epidermis from psoriasis patients in the middle and late stages of NB-UVB phototherapy. The earliest response to phototherapy was increased melanogenesis gene expression.

At the conclusion of treatment, genes responding to phototherapy and correlated to treatment outcome were involved in oxidation reduction, growth and mitochondria organization. They found that SPATA18, a key regulator of mitochondrial quality, was significantly down regulated in psoriasis (P <0.05). Poly(dA:dT) and poly(I:C) stimulation increased SPATA18 level in primary keratinocytes, indicating the importance of mitochondria quality control underinnate immune induced oxidative stress.

“Normalized SPATA18 expression after phototherapy indicates improved mitochondrial quality control and restored cellular redox status. Our data suggest that oxidation reduction is critical for the resolution of psoriatic plaques following NB-UVB phototherapy,” they concluded.
 
Gu X, Nylander E, Coates PJ, Nylander K. Oxidation reduction is a key process for successful treatment of psoriasis by narrow-band UVB phototherapy. Acta Derm Venereol. Published online ahead of print June 5, 2014.