News: Regular Comorbidity Screening Needed for Children With Psoriasis, and More

08/02/2017

Regular Comorbidity Screening Needed for Children With Psoriasis

Patients with pediatric psoriasis should receive routine screening and identification of risk factors for associated comorbidities, according to a consensus statement published online in JAMA Dermatology.

These guidelines are relevant for all health care providers caring for patients with pediatric psoriasis, including primary care clinicians, dermatologists, and pediatric specialists. Because these are the first pediatric guidelines, re-review and refinement will be necessary as studies further detail, and possibly stratify, risk in affected children, noted the researchers.

Psoriasis is associated with serious medical comorbidities in adults, including obesity, hypertension, dyslipidemia, type 2 diabetes mellitus, psoriatic arthritis, nonalcoholic fatty liver disease, depression, anxiety, and decreased quality of life. Because psoriasis begins in childhood in almost one-third of patients, early identification of risk may be critical to minimizing effects on future health.

The panel, comprised of experts in psoriasis, pediatric dermatology, pediatric rheumatology, pediatric gastroenterology, pediatric endocrinology, and adult and pediatric cardiology, developed the first set of guidelines for comorbidity screening for patients with pediatric psoriasis based on current evidence. A literature review was performed using PubMed from January 1999 through December 2015. Limiting the search to human studies published in English and eliminating reviews and editorials produced 153 relevant manuscripts.

The panel used the patient-centered Strength of Recommendation Taxonomy (SORT) method to evaluate and grade the quality of evidence.

Many recommendations are similar to those endorsed by the American Academy of Pediatrics for the general pediatric patient. They include annual screening for overweight and obesity beginning at age 2 years; screening of overweight patients every 3 years for type 2 diabetes beginning at age 10 years; lipid screening between ages 9 to 11 years and between ages 17 to 21 years; annual screening for hypertension beginning at age 3 years; and screening for nonalcoholic fatty liver disease for children with risk factors. The panel also recommended screening for signs and symptoms of arthritis, depression, and anxiety.

Due to the limited number of pediatric studies published on these topics, the strength of the panel’s recommendations is classified as SORT level C expert consensus recommendations. The panel also identified key areas for further investigation.

Reference

Osier E, Wang AS, Tollefson MM, et al. Pediatric psoriasis comorbidity screening guidelines [published online May 17, 2017]. JAMA Dermatol. doi:10.1001/jamadermatol.2017.0499

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