Multiple Cycles of Phototherapy Yield Shorter Remission Periods

A recent study found that psoriasis patients who have previously undergone multiple phototherapy treatments experience shorter remission periods when being treated with narrowband ultraviolet B (NB-UVB) phototherapy. Ryu et al conducted a study to determine the duration of remission periods experienced by psoriasis patients after NB- UVB, with a focus on patients who received multiple cycles of treatment.
The study included 63 patients who showed improvement after NB-UVB phototherapy. The researchers defined the remission period as the duration of time from the end of a phototherapy treatment cycle until treatment using phototherapy or systemic treatments was required again.
The study found that ≥3 phototherapy cycles within 6 months of systemic therapy is significantly associated with shorter remission times, particularly in patients ≥ 60 years of age. A multivariate analysis confirmed that ≥ 3 phototherapy cycles (odds ratio [OR], 4; 95% confidence interval [CI], 1.73-9.33; P=.001) and a history of systemic therapy (OR, 2.2; 95% CI, 1.27-3.95; P=.005) were independently associated with short remission times.
These findings indicate that the more phototherapy a psoriasis patient is exposed to, the less effective NB- UVB phototherapy may become for remission time, they concluded. The researchers suggested clinicians consider these findings when contemplating NB-UVB on psoriasis patients that have undergone multiple phototherapy treatments.
Ryu HH, Choe YS, Jo S, Youn JI, Jo SJ. Remission period in psoriasis after multiple cycles of narrowband ultraviolet B phototherapy. J Dermatol. 2014;41(7):622-62.