Cetaphil® RestoraDerm® Skin Care Regimen for Atopic Dermatitis


Atopic dermatitis (AD) is a chronic, relapsing, inflammatory disease that manifests as an itchy inflammation of the skin.1,2 Also known as eczema, AD is one of the most common skin disorders in young children.1,3,4 It is estimated that 10% to 20% of the US pediatric population suffers from AD within the first decade of their life.3-5 Disease onset typically occurs before the age of 5 in 90% of children, with 60% experiencing symptoms in the first year of life.6
AD is often the first clinical manifestation of the atopic march, which is the typical progression of allergic diseases that often begin early in life. It is also associated with other atopic diseases, including asthma, allergic rhinitis, and extrinsic allergies.3,4 AD can occur anywhere, but the face is often the first area affected.7


In order to understand the mechanics behind AD, one needs to understand the basic structures needed to maintain healthy skin hydration. Filaggrin and ceramides are the central components of skin that are affected by AD. Filaggrin, for example, is a vital protein required for the structural formation and hydration of the stratum corneum (SC), which is the outermost layer of the epidermis. Of equal significance, ceramides are a combination of fatty acids and a sphingoid base joined by an amide bond between the carboxyl group of the fatty acid and the amino acid group of the base.8-10
Filaggrin is the precursor protein for the amino-acid derived components of the natural moisturizing factor (NMF) and is one of the most significant influences on water flux and maintaining healthy moisture levels in the skin.11 Defective filaggrin production, altered enzyme activity, modification in the lipid composition, and a decrease in subfractions of ceramides are some of the factors that contribute to an altered permeability barrier and reduced moisture content in the SC.12
Ceramides are the most common constituent among SC lipids, accounting for up to 50% of total intercellular lipids and are important for lateral lipid packing and permeability.13-16 AD lesional skin typically demonstrates lower levels of ceramide—particularly ceramides 1 and 3—and NMF, elevated pH, altered antimicrobial peptide production, reduced hydration, reduced cornified envelop protein expression, including filaggrin breakdown products, and elevated transepidermal water loss (TEWL).5
Pruritus (ie, itching) is a key symptom associated with AD, leading to a vicious cycle of itching and scratching, which further compromises the already damaged skin.1 Specifically in the pediatric patient, the “itch-scratch-itch” cycle is common and scratching of the intensely irritated skin further compromises the epidermal barrier and leads to increased water loss, extreme dry skin, microbial colonization, and secondary infections.7 Needless to say, it is very difficult to prevent a child from scratching a persistent itch. Extreme itching is also associated with sleep loss, which can add to the distress of a patient.6


Treating AD in the pediatric patient is often difficult for pediatricians and dermatologists due to the chronic and relapsing characteristics of the disease. While topical steroids are typically the first-line treatment strategy during flares, the foundation of a long-term AD management plan, including a daily skin care regimen that includes both cleansers and moisturizers, is crucial to controlling and preventing flares.1
In general, moisturizers are designed to maintain the water content of the skin, including ingredients such as occlusives, humectants, and emollients. Occlusives, such as petrolatum, dimethicone, and mineral oil, minimize the evaporation of water. Humectants act from the inside out to attract water from the deeper layers of the skin to the epidermis, and from the outside in, attracting moisture from the outside environment, while emollients make the skin feel soft and supple. High quality moisturizers typically contain all 3 of these ingredients.8


Cetaphil® RestoraDerm® is the first and only regimen with advanced ceramide and filaggrin technologyTM that helps to replenish the skin barrier. The advanced ceramide technology also enhances the skin’s natural ability to retain moisture.1,7,17,18
Cetaphil® RestoraDerm® skin care products are formulated with arginine and sodium pyrrolidone carboxylic acid, both of which are filaggrin breakdown products. Specific ingredients include pseudoceramide-5, niacinamide, fatty acids, pyrrolidone carboxylic acid, humectants, filmogenic substances, emollients, and shea butter.6 Together, these combined ingredients selected for Cetaphil® RestoraDerm® Moisturizer help replenish the skin’s natural lipids and restore moisture to the damaged epidermal barrier.8,17,19-24
Cetaphil® RestoraDerm® Skin Restoring Body Wash ingredients have also been carefully selected and combined to help replenish the skin’s natural lipids and restore moisture to the damaged epidermal barrier to support the treatment plan. In addition, both the Cetaphil® RestoraDerm® Body Wash and Moisturizer contain shea butter, sunflower seed oil, glycerin, niacinamide, and are specially formulated for atopic skin. These products are the only known over-the-counter products with this unique formulation designed to address the cleansing and moisturizing challenges associated with AD.7
Cetaphil® RestoraDerm® also meets the specific needs of children and adults with AD.5 For children with AD, regular bathing is recommended once daily for several minutes using warm rather than hot water, followed by a moisturizing cleanser. Liberal amounts of moisturizer should then be applied following bathing before the skin has dried completely in order to prevent dryness and irritation.6
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