Skip to main content

What Condition Does This Woman With Scleral Dyschromia Have?

What Condition Does This Woman With Scleral Dyschromia Have?

Article Type
Disclosures

The authors report no relevant financial relationships.

Ms Laborada is a medical student at the University of California Riverside School of Medicine in Riverside, CA. Dr Cohen is an adjunct professor of dermatology at Touro University California College of Osteopathic Medicine in Vallejo, CA, and a dermatologist at San Diego Family Dermatology in National City, CA.

References

  1. Arundel P. Osteogenesis imperfecta. Paediatr Child Health. 2015;25(12):574-579. doi:0.1016/j.paed.2015.07.007
  2. Sillence DO, Senn A, Danks DM. Genetic heterogeneity in osteogenesis imperfecta. J Med Genet. 1979;16(2):101-116. doi:10.1136/jmg.16.2.101
  3. Valadares ER, Carneiro TB, Santos PM, Oliveira AC, Zabel B. What is new in genetics and osteogenesis imperfecta classification? J Pediatr (Rio J). 2014;90(6):536-541. doi:10.1016/j.jped.2014.05.003
  4. Tournis S, Dede AD. Osteogenesis imperfecta - a clinical update. Metabolism. 2018;80:27-37. doi:10.1016/j.metabol.2017.06.001
  5. Wilcox RA, McDonald FS. Gray-blue sclerae and osteopenia secondary to osteogenesis imperfecta. Mayo Clin Proc. 2007;82(3):265. doi:10.4065/82.3.265
  6. Brooks, JK. A review of syndromes associated with blue sclera, with inclusion of malformations of the head and neck. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018;126(3):252-263. doi:10.1016/j.oooo.2018.05.012
  7. Goette A, Huth C, Behrens-Baumann W, Evert M. Severe mitral regurgitation in a patient with a bluish right sclera: an ‘extension’ of Caplan’s syndrome to the heart and eye. Eur J Intern Med. 2009;20(1):e1-e2. doi:10.1016/j.ejim.2007.06.027
  8. Marion RW, Wiznia AA, Hutcheon G, Rubinstein A. Human T-cell lymphotropic virus type III (HTLV-III) embryopathy. A new dysmorphic syndrome associated with intrauterine HTLV-III infection. Am J Dis Child. 1986;140(7):638-640. doi:10.1001/archpedi.1986.02140210036020
  9. Rathi A, Takkar B, Azad S. Ectopic lentis and blue sclera in hyperhomocysteinaemia. Natl Med J India. 2017;30(3):176.
  10. Hassen GW, Chirurgi R, Kalanrari H. Blue sclera secondary to severe iron deficiency anemia. QJM. 2017;110(12):835-836. doi:10.1093/qjmed/hcx163
  11. Wiernik PH. Blue sclerae. Lancet. 1972;2(7788):1199. doi:10.1016/s0140-6736(72)92624-4
  12. Sehgal VN, Syed NH, Aggarwal A, Sharma S, Sehgal S. Nevus of Ota/oculodermal melanocytosis: a rare report of an oral mucosal lesion involving the hard palate. Cutis. 2015;96(4):E10-E12.
  13. Limvorapitak W, Villa D. Acquired blue sclerae in POEMS syndrome. Br J Haematol. 2017;177(4):508. doi:10.1111/bjh.14646
  14. Johnston S. Feeling blue? Minocycline-induced staining of the teeth, oral mucosa, sclerae and ears – a case report. Br Dent J. 2013;215(2):71-73. doi:10.1038/sj.bdj.2013.682
  15. Reese S, Grundfast K. Minocycline-induced hyperpigmentation of tympanic membrane, sclera, teeth, and pinna. Laryngoscope. 2015;125(11):2601-2603. doi:10.1002/lary.25365
  16. Leyden MJ, Sullivan JR, Cheng ZM, Russell IS, Collins J. Unusual side effect of mitoxantrone. Med J Aust. 1983;2(10):514. doi:10.5694/j.1326-5377.1983.tb122624.x
  17. Henderson RP, Lander R. Scleral discoloration associated with long-term prednisone administration. Cutis. 1984;34(1):76-77.
  18. Clark S, Antell A, Kaufman K. New antiepileptic medication linked to blue discoloration of the skin and eyes. Ther Adv Drug Saf. 2015;6(1):15-19. doi:10.1177/2042098614560736
  19. Kim Y, Suh HS, Cha HJ, Kim SH, Jeong KS, Kim DH. A case of generalized argyria after ingestion of colloidal silver solution. Am J Ind Med. 2009;52(3):246-250. doi:10.1002/ajim.20670
  20. Smith RW, Leppard B, Barnett NL, Millward-Sadler GH, McCrae F, Cawley MI. Chrysiasis revisited: a clinical and pathologic study. Br J Dermatol. 1995;133(5):671-678. doi:10.1111/j.1365-2133.1995.tb02737.x
  21. Malfait F, De Coster P, Hausser I, et al. The natural history, including orofacial features of three patients with Ehlers-Danlos syndrome, dermatosparaxis type (EDS type VIIC). Am J Med Genet A. 2004;131(1):18-28. doi:10.1002/ajmg.a.30299
  22. Albers SE, Brozena SJ, Glass LF, Fenske NA. Alkaptonuria and ochronosis: case report and review. J Am Acad Dermatol. 1992;27(4):609-614. doi:10.1016/0190-9622(92)70230-d
  23. Azami A, Maleki N, Tavosi Z. Alkaptonuric ochronosis: a clinical study from Ardabil, Iran. Int J Rheum Dis. 2014;17(3):327-332. doi:10.1111/1756-185X.12287
  24. Shetty SR, Subhas BG, Rao KA, Castellino R. Nevus of ota with buccal mucosal pigmentation: a rare case. Dent Res J (Isfahan). 2011;8(1):52-55.
  25. Wang W, Fujiwara S, Seguchi S, Yokoyama S, Mizoguchi M. Acquired dermal melanocytosis: a case with conjunctival and gingival pigmentation. J Dermatol.  2004;31(9):752-755. doi:10.1111/j.1346-8138.2004.tb00590.x
  26. Forlino A, Marini JC. Osteogenesis imperfecta. Lancet. 2016;387(10028):1657-1671. doi:10.1016/S0140-6736(15)00728-X.
Back to Top