Study Finds Link Between AD and Bone Disorders
A study conducted by Mohammed S. Shaheen, JD, with the department of dermatology at Northwestern University Feinberg School of Medicine, and Jonathon I. Silverberg, MD, PhD, MPH, assistant professor of dermatology at Northwestern University Feinberg School of Medicine, found a positive association between atopic dermatitis (AD) and osteopenia and osteoporosis.1 Their findings confirm similar observations made in other studies on the relationship between AD and bone disorders.
“We previously studied the relationship between AD and bone mineral density in children and adults and found highly significant associations with lower bone mineral density overall and higher rates of osteopenia and osteoporosis,” said Dr Silverberg. “Together, the results suggest that AD patients of all ages may be at an increased risk of osteopenia and osteoporosis.”
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In their study, Mr Shaheen and Dr Silverberg analyzed data from the 2006-2012 Nationwide Emergency Department Sample (NEDS) database and the 2002-2012 National Inpatient Sample (NIS), which included 61,065,660 and 44,425,777 encounters for persons aged 50 years and older, respectively.
The primary or secondary International Classification of Disease, Ninth Revision, Clinical Modification codes were used to identify incidents of AD, osteoporosis, and osteopenia. Multivariable logistic regression models were used to examine the association between AD and osteoporosis and osteopenia, with age, sex, race/ethnicity, insurance, and household income quartile included as covariates.
Their findings showed that AD was associated with higher odds of osteoporosis in NEDS (adjusted odd ratio [OR], 1.31; 95% CI, 1.12-1.54) and NIS (OR, 1.25; 95% CI, 1.24-1.26), and osteopenia in NEDS (OR, 1.86; 95% CI, 1.36-2.55). In addition, sensitivity analyses of patients aged 70 years and older found AD was associated with higher odds of osteoporosis in NEDS (OR, 1.37; 95% CI, 1.12-1.67) and in NIS (OR, 1.24; 95% CI, 1.22-1.25), and osteopenia in NEDS (OR, 1.84; 95% CI, 1.20-2.82).
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